MOTS-c
Mitochondrial-derived peptide (MOTS-c) investigated in metabolic regulation and cellular-energy research. High-purity, third-party tested reference material with a COA. RUO.
| Purity (HPLC) | ≥ 99.0% |
|---|---|
| Available sizes | 10 mg, 40 mg |
| Physical form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded not in nuclear DNA but within the mitochondrial genome itself — one of a small class of mitochondrial-derived peptides. That origin is what makes it interesting: it signals outward from the mitochondria to the nucleus, a direction of communication only recognised relatively recently.
It is supplied as a lyophilized powder and reconstituted before in-vitro work. Our reconstitution guide covers technique, and the reconstitution calculator works out the dilution for either vial size.
Research context
Research models examine MOTS-c in metabolic homeostasis, insulin sensitivity and the cellular stress response, frequently through AMPK signalling and folate-cycle metabolism. Because it sits at the intersection of energy metabolism and cellular aging, it appears in both metabolic and longevity study designs.
In metabolic work it is often examined alongside receptor-level compounds such as Retatrutide and Tirzepatide, which act on entirely different mechanisms — see the overview of metabolic research peptides. In cellular-energetics work the natural comparators are SS-31 and NAD+.
Purity and third-party testing
Every batch is independently analysed by Testides and Peptide Test Canada and ships with a certificate of analysis reporting HPLC purity and MS identity. See how to read a certificate of analysis and what a purity figure actually means, or read about our testing on the Research and Quality page.
Handling and storage
Kept cold and protected from light in its lyophilized state; refrigerated and used within a shorter window once reconstituted. The storage guide covers both, and bacteriostatic vs. sterile water explains why bacteriostatic water suits a vial sampled repeatedly — relevant for the 40 mg size.
Related research compounds
MOTS-c appears in both our metabolic and weight-research collection and our longevity collection, alongside Epithalon. New to this area? Start with Peptides 101 or the knowledge hub.
Research Use Only. Supplied strictly for in-vitro laboratory research and development. Not for human or animal consumption, diagnostic, or therapeutic use.
Frequently asked
No. MOTS-c is supplied strictly as a reference material for in-vitro laboratory research. It is not for human or animal consumption and is not intended for diagnostic or therapeutic use.
Yes. Every batch is independently tested by Testides and Peptide Test Canada for HPLC purity and mass-spectrometry identity, and ships with a batch-specific certificate of analysis (COA).
MOTS-c is available in 10 mg, 40 mg. Per-vial pricing is shown on this page.
MOTS-c is supplied as lyophilized powder. Use the reconstitution calculator to work out concentration and dosing volumes for your research, and see the storage and handling guide for temperature and shelf-life guidance. Store the lyophilized vial at -20 degrees C, desiccated and protected from light.
What researchers say
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Please review the material itself — purity, packaging, shipping and handling. We cannot publish reviews describing human or animal use, dosing, or health outcomes, because everything we supply is strictly for in-vitro laboratory research. Every review is read before it appears.
